The Post-Translational Modifications of Human Salivary Peptides and Proteins Evidenced by Top-Down Platforms

In this review, we extensively describe the main post-translational modifications that give rise to multiple proteoforms characterized date in human salivary proteome and their potential role. Most of data reported were obtained by our group over twenty-five years research carried out on saliva mainly applying a top-down strategy. beginning, products generated proteolytic cleavages, which can occur before after secretion. section, most relevant families proteins are also described. Next, report current information concerning phospho-proteome limited news available sulfo-proteomes. Three sections dedicated description glycation enzymatic glycosylation. Citrullination N- C-terminal (PTMs) miscellaneous other described last two sections. Results highlighting variation level some local or systemic pathologies reviewed throughout manuscript underline impact relevance for development new diagnostic biomarkers useful clinical practice.